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Improving the Sensitivity, Resolution, and Peak Capacity of Gradient Elution in Capillary Liquid Chromatography with Large-Volume Injections by Using Temperature-Assisted On-Column Solute Focusing

Capillary HPLC (cLC) with gradient elution is the separation method of choice for the fields of proteomics and metabolomics. This is due to the complementary nature of cLC flow rates and electrospray or nanospray ionization mass spectrometry (ESI-MS). The small column diameters result in good mass s...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Anal Chem
Main Authors: Wilson, Rachael E., Groskreutz, Stephen R., Weber, Stephen G.
Format: Artigo
Jezik:Inglês
Izdano: 2016
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4940048/
https://ncbi.nlm.nih.gov/pubmed/27033165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.analchem.5b04793
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