Pros and cons of methylation-based enrichment methods for ancient DNA

The recent discovery that DNA methylation survives in fossil material provides an opportunity for novel molecular approaches in palaeogenomics. Here, we apply to ancient DNA extracts the probe-independent Methylated Binding Domains (MBD)-based enrichment method, which targets DNA molecules containin...

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Vydáno v:Sci Rep
Hlavní autoři: Seguin-Orlando, Andaine, Gamba, Cristina, Sarkissian, Clio Der, Ermini, Luca, Louvel, Guillaume, Boulygina, Eugenia, Sokolov, Alexey, Nedoluzhko, Artem, Lorenzen, Eline D., Lopez, Patricio, McDonald, H. Gregory, Scott, Eric, Tikhonov, Alexei, Stafford,, Thomas W., Alfarhan, Ahmed H., Alquraishi, Saleh A., Al-Rasheid, Khaled A. S., Shapiro, Beth, Willerslev, Eske, Prokhortchouk, Egor, Orlando, Ludovic
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4488743/
https://ncbi.nlm.nih.gov/pubmed/26134828
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep11826
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