Pros and cons of methylation-based enrichment methods for ancient DNA

The recent discovery that DNA methylation survives in fossil material provides an opportunity for novel molecular approaches in palaeogenomics. Here, we apply to ancient DNA extracts the probe-independent Methylated Binding Domains (MBD)-based enrichment method, which targets DNA molecules containin...

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Publicado en:Sci Rep
Main Authors: Seguin-Orlando, Andaine, Gamba, Cristina, Sarkissian, Clio Der, Ermini, Luca, Louvel, Guillaume, Boulygina, Eugenia, Sokolov, Alexey, Nedoluzhko, Artem, Lorenzen, Eline D., Lopez, Patricio, McDonald, H. Gregory, Scott, Eric, Tikhonov, Alexei, Stafford,, Thomas W., Alfarhan, Ahmed H., Alquraishi, Saleh A., Al-Rasheid, Khaled A. S., Shapiro, Beth, Willerslev, Eske, Prokhortchouk, Egor, Orlando, Ludovic
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2015
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4488743/
https://ncbi.nlm.nih.gov/pubmed/26134828
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep11826
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