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Solid-State NMR Spectroscopy of Human Immunodeficiency Virus Fusion Peptides Associated with Host-Cell-Like Membranes: 2D Correlation Spectra and Distance Measurements Support a Fully Extended Conformation and Models for Specific Antiparallel Strand Registries

The human immunodeficiency virus (HIV) is “enveloped” by a membrane, and infection of a host cell begins with fusion between viral and target cell membranes. Fusion is catalyzed by the HIV gp41 protein which contains a functionally critical ~20-residue apolar “fusion peptide” (HFP) that associates w...

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Detalhes bibliográficos
Publicado no:J Am Chem Soc
Main Authors: Qiang, Wei, Bodner, Michele L., Weliky, David P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4487652/
https://ncbi.nlm.nih.gov/pubmed/18370385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja077302m
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