Phase I/II study of the hypoxia-activated prodrug PR104 in refractory/relapsed acute myeloid leukemia and acute lymphoblastic leukemia

We previously demonstrated vast expansion of hypoxic areas in the leukemic microenvironment and provided a rationale for using hypoxia-activated prodrugs. PR104 is a phosphate ester that is rapidly hydrolyzed in vivo to the corresponding alcohol PR-104A and further reduced to the amine and hydroxyl-...

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Foilsithe in:Haematologica
Main Authors: Konopleva, Marina, Thall, Peter F., Yi, Cecilia Arana, Borthakur, Gautam, Coveler, Andrew, Bueso-Ramos, Carlos, Benito, Juliana, Konoplev, Sergej, Gu, Yongchuan, Ravandi, Farhad, Jabbour, Elias, Faderl, Stefan, Thomas, Deborah, Cortes, Jorge, Kadia, Tapan, Kornblau, Steven, Daver, Naval, Pemmaraju, Naveen, Nguyen, Hoang Q., Feliu, Jennie, Lu, Hongbo, Wei, Caimiao, Wilson, William R., Melink, Teresa J., Gutheil, John C., Andreeff, Michael, Estey, Elihu H., Kantarjian, Hagop
Formáid: Artigo
Teanga:Inglês
Foilsithe: Ferrata Storti Foundation 2015
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Articles
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4486227/
https://ncbi.nlm.nih.gov/pubmed/25682597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2014.118455
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