A naturally occurring variant of the human prion protein completely prevents prion disease

Mammalian prions, transmissible agents causing lethal neurodegenerative diseases, are composed of assemblies of misfolded cellular prion protein (PrP) (1). A novel PrP variant, G127V, was under positive evolutionary selection during the epidemic of kuru, an acquired prion disease epidemic of the For...

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Vydáno v:Nature
Hlavní autoři: Asante, Emmanuel A., Smidak, Michelle, Grimshaw, Andrew, Houghton, Richard, Tomlinson, Andrew, Jeelani, Asif, Jakubcova, Tatiana, Hamdan, Shyma, Richard-Londt, Angela, Linehan, Jacqueline M., Brandner, Sebastian, Alpers, Michael, Whitfield, Jerome, Mead, Simon, Wadsworth, Jonathan D.F., Collinge, John
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4486072/
https://ncbi.nlm.nih.gov/pubmed/26061765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature14510
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