A naturally occurring variant of the human prion protein completely prevents prion disease

Mammalian prions, transmissible agents causing lethal neurodegenerative diseases, are composed of assemblies of misfolded cellular prion protein (PrP) (1). A novel PrP variant, G127V, was under positive evolutionary selection during the epidemic of kuru, an acquired prion disease epidemic of the For...

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Publicado no:Nature
Main Authors: Asante, Emmanuel A., Smidak, Michelle, Grimshaw, Andrew, Houghton, Richard, Tomlinson, Andrew, Jeelani, Asif, Jakubcova, Tatiana, Hamdan, Shyma, Richard-Londt, Angela, Linehan, Jacqueline M., Brandner, Sebastian, Alpers, Michael, Whitfield, Jerome, Mead, Simon, Wadsworth, Jonathan D.F., Collinge, John
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4486072/
https://ncbi.nlm.nih.gov/pubmed/26061765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature14510
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