The truncated splice variant of peroxisome proliferator-activated receptor alpha, PPARα-tr, autonomously regulates proliferative and pro-inflammatory genes

BACKGROUND: The peroxisome proliferator-activated receptor alpha (PPARα) controls lipid/energy homeostasis and inflammatory responses. The truncated splice variant PPARα-tr was suggested to exert a dominant negative function despite being unable to bind consensus PPARα DNA response elements. METHODS...

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Foilsithe in:BMC Cancer
Main Authors: Thomas, Maria, Bayha, Christine, Klein, Kathrin, Müller, Simon, Weiss, Thomas S., Schwab, Matthias, Zanger, Ulrich M.
Formáid: Artigo
Teanga:Inglês
Foilsithe: BioMed Central 2015
Ábhair:
Research Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4485637/
https://ncbi.nlm.nih.gov/pubmed/26122096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-015-1500-x
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