A novel PI3K inhibitor iMDK suppresses non-small cell lung Cancer cooperatively with A MEK inhibitor

The PI3K–AKT pathway is expected to be a therapeutic target for non-small cell lung cancer (NSCLC) treatment. We previously reported that a novel PI3K inhibitor iMDK suppressed NSCLC cells in vitro and in vivo without harming normal cells and mice. Unexpectedly, iMDK activated the MAPK pathway, incl...

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Publicat a:Exp Cell Res
Autors principals: Ishida, Naomasa, Fukazawa, Takuya, Maeda, Yutaka, Yamatsuji, Tomoki, Takaoka, Munenori, Haisa, Minoru, Yokota, Etsuko, Shigemitsu, Kaori, Morita, Ichiro, Kato, Katsuya, Matsumoto, Kenichi, Shimo, Tsuyoshi, Okui, Tatsuo, Bao, Xiao-Hong, Hao, Huifang, Grant, Shawn N., Takigawa, Nagio, Whitsett, Jeffrey A., Naomoto, Yoshio
Format: Artigo
Idioma:Inglês
Publicat: 2015
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4485577/
https://ncbi.nlm.nih.gov/pubmed/25839409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yexcr.2015.03.019
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