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Supercharged green fluorescent proteins as bimodal reporter genes for CEST MRI and optical imaging

Superpositively charged mutants of green fluorescent protein (GFP) demonstrated a dramatically improved chemical exchange saturation transfer (CEST) MRI contrast compared to their wild type counterparts. The mutants +36 GFP and +48 GFP were successfully expressed in mammalian cells and retained part...

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Détails bibliographiques
Publié dans:Chem Commun (Camb)
Auteurs principaux: Bar-Shir, Amnon, Liang, Yajie, Chan, Kannie W. Y., Gilad, Assaf A., Bulte, Jeff W. M.
Format: Artigo
Langue:Inglês
Publié: 2015
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4485562/
https://ncbi.nlm.nih.gov/pubmed/25697683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c4cc10195b
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