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Acceleration of protein folding by four orders of magnitude through a single amino acid substitution
Cis prolyl peptide bonds are conserved structural elements in numerous protein families, although their formation is energetically unfavorable, intrinsically slow and often rate-limiting for folding. Here we investigate the reasons underlying the conservation of the cis proline that is diagnostic fo...
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| Publicado no: | Sci Rep |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4485320/ https://ncbi.nlm.nih.gov/pubmed/26121966 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep11840 |
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