How Does Thymus Infection by Coxsackievirus Contribute to the Pathogenesis of Type 1 Diabetes?

Through synthesis and presentation of neuroendocrine self-antigens by major histocompatibility complex proteins, thymic epithelial cells (TECs) play a crucial role in programing central immune self-tolerance to neuroendocrine functions. Insulin-like growth factor-2 (IGF-2) is the dominant gene/polyp...

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Vydáno v:Front Immunol
Hlavní autoři: Michaux, Hélène, Martens, Henri, Jaïdane, Hela, Halouani, Aymen, Hober, Didier, Geenen, Vincent
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2015
Témata:
Immunology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4485212/
https://ncbi.nlm.nih.gov/pubmed/26175734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2015.00338
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