HIV Pre-Exposure Prophylaxis: Mucosal Tissue Drug Distribution of RT Inhibitor Tenofovir and Entry Inhibitor Maraviroc in a Humanized Mouse Model

Pre-exposure prophylaxis (PrEP) strategies utilizing anti-retroviral drugs show considerable promise for HIV prevention. However there is insufficient pharmacokinetic (PK) data on drug concentrations required for protection at the relevant mucosal tissues where the infection is initiated. Here we ev...

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Publicado no:Virology
Main Authors: Veselinovic, Milena, Yang, Kuo-Hsiung, LeCureux, Jonathan, Sykes, Craig, Remling-Mulder, Leila, Kashuba, Angela DM, Akkina, Ramesh
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4484790/
https://ncbi.nlm.nih.gov/pubmed/25105490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2014.07.008
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