Impaired NFAT and NFκB Activation are Involved in Suppression of CD40 Ligand Expression by Δ(9)-Tetrahydrocannabinol in Human CD4(+) T cells

We have previously reported that Δ(9)-tetrahydrocannabinol (Δ(9)-THC), the main psychoactive cannabinoid in marijuana, suppresses CD40 ligand (CD40L) expression by activated mouse CD4(+) T cells. CD40L is involved in pathogenesis of many autoimmune and inflammatory diseases. In the present study, we...

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Vydáno v:Toxicol Appl Pharmacol
Hlavní autoři: Ngaotepprutaram, Thitirat, Kaplan, Barbara L.F., Kaminski, Norbert E.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4484623/
https://ncbi.nlm.nih.gov/pubmed/23999542
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.taap.2013.08.023
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