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Relative replication fitness of efavirenz-resistant mutants of HIV-1: Correlation with frequency during clinical therapy and evidence of compensation for the reduced fitness of K103N + L100I by the nucleoside resistance mutation L74V

Efavirenz resistance during HIV-1 treatment failure is usually associated with the reverse transcriptase mutation K103N. L100I, V108I, or P225H can emerge after K103N and increase its level of efavirenz resistance. K103N + L100I is the most drug-resistant of the double mutants but is the least commo...

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Dettagli Bibliografici
Pubblicato in:Virology
Autori principali: Koval, Christine E., Dykes, Carrie, Wang, Jiong, Demeter, Lisa M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2006
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4484603/
https://ncbi.nlm.nih.gov/pubmed/16797050
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2006.05.021
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