FTY720 enhances TRAIL-mediated apoptosis by up-regulating DR5 and down-regulating Mcl-1 in cancer cells

FTY720, Fingolimod, is a functional antagonist to the sphingosine-1-phoaphate (S1P) receptor and an inhibitor of sphingosine kinase 1. Here, we showed that a combination of FTY720 and TRAIL induced apoptosis in human renal, breast, and colon carcinoma cells. Most importantly, this combination had no...

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Опубликовано в: :Oncotarget
Главные авторы: Woo, Seon Min, Seo, Bo Ram, Min, Kyoung-jin, Kwon, Taeg Kyu
Формат: Artigo
Язык:Inglês
Опубликовано: Impact Journals LLC 2015
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Research Paper
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4484480/
https://ncbi.nlm.nih.gov/pubmed/25843953
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