The pan-PI3K inhibitor GDC-0941 activates canonical WNT signaling to confer resistance in TNBC cells: resistance reversal with WNT inhibitor

The pan-PI3K inhibitors are one treatment option for triple-negative breast cancer (TNBC). However, this treatment is ineffective for unknown reasons. Here, we report that aberrant expression of wingless-type MMTV integration site family (WNT) and activated WNT signals, which crosstalk with the PI3K...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Tzeng, Huey-En, Yang, Lixin, Chen, Kemin, Wang, Yafan, Liu, Yun-Ru, Pan, Shiow-Lin, Gaur, Shikha, Hu, Shuya, Yen, Yun
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4484439/
https://ncbi.nlm.nih.gov/pubmed/25857298
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