Metformin prevents aggressive ovarian cancer growth driven by high-energy diet: similarity with calorie restriction

Caloric restriction (CR) was recently demonstrated by us to restrict ovarian cancer growth in vivo. CR resulted in activation of energy regulating enzymes adenosine monophosphate activated kinase (AMPK) and sirtuin 1 (SIRT1) followed by downstream inhibition of Akt-mTOR. In the present study, we inv...

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Bibliographic Details
Published in:Oncotarget
Main Authors: Al-Wahab, Zaid, Mert, Ismail, Tebbe, Calvin, Chhina, Jasdeep, Hijaz, Miriana, Morris, Robert T., Ali-Fehmi, Rouba, Giri, Shailendra, Munkarah, Adnan R., Rattan, Ramandeep
Format: Artigo
Language:Inglês
Published: Impact Journals LLC 2015
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4484428/
https://ncbi.nlm.nih.gov/pubmed/25895126
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