Metformin prevents aggressive ovarian cancer growth driven by high-energy diet: similarity with calorie restriction

Caloric restriction (CR) was recently demonstrated by us to restrict ovarian cancer growth in vivo. CR resulted in activation of energy regulating enzymes adenosine monophosphate activated kinase (AMPK) and sirtuin 1 (SIRT1) followed by downstream inhibition of Akt-mTOR. In the present study, we inv...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Al-Wahab, Zaid, Mert, Ismail, Tebbe, Calvin, Chhina, Jasdeep, Hijaz, Miriana, Morris, Robert T., Ali-Fehmi, Rouba, Giri, Shailendra, Munkarah, Adnan R., Rattan, Ramandeep
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4484428/
https://ncbi.nlm.nih.gov/pubmed/25895126
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