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Activation of Notch3 in Glomeruli Promotes the Development of Rapidly Progressive Renal Disease

Notch3 expression is found in the glomerular podocytes of patients with lupus nephritis or focal segmental GN but not in normal kidneys. Here, we show that activation of the Notch3 receptor in the glomeruli is a turning point inducing phenotypic changes in podocytes promoting renal inflammation and...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Am Soc Nephrol
Prif Awduron: El Machhour, Fala, Keuylian, Zela, Kavvadas, Panagiotis, Dussaule, Jean-Claude, Chatziantoniou, Christos
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society of Nephrology 2015
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4483574/
https://ncbi.nlm.nih.gov/pubmed/25421557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2013090968
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