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Activation of Notch3 in Glomeruli Promotes the Development of Rapidly Progressive Renal Disease
Notch3 expression is found in the glomerular podocytes of patients with lupus nephritis or focal segmental GN but not in normal kidneys. Here, we show that activation of the Notch3 receptor in the glomeruli is a turning point inducing phenotypic changes in podocytes promoting renal inflammation and...
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| Veröffentlicht in: | J Am Soc Nephrol |
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| Hauptverfasser: | , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society of Nephrology
2015
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4483574/ https://ncbi.nlm.nih.gov/pubmed/25421557 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2013090968 |
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