Intracellular Clusterin Inhibits Mitochondrial Apoptosis by Suppressing p53-Activating Stress Signals and Stabilizing the Cytosolic Ku70-Bax Protein Complex

PURPOSE: Secretory clusterin (sCLU)/apolipoprotein J is an extracellular chaperone that has been functionally implicated in DNA repair, cell cycle regulation, apoptotic cell death, and tumorigenesis. It exerts a prosurvival function against most therapeutic treatments for cancer and is currently an...

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Udgivet i:Clin Cancer Res
Main Authors: Trougakos, Ioannis P., Lourda, Magda, Antonelou, Marianna H., Kletsas, Dimitris, Gorgoulis, Vassilis G., Papassideri, Issidora S., Zou, Yonglong, Margaritis, Lukas H., Boothman, David A., Gonos, Efstathios S.
Format: Artigo
Sprog:Inglês
Udgivet: 2009
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4483278/
https://ncbi.nlm.nih.gov/pubmed/19118032
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-08-1805
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