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Genome-wide search for loss of heterozygosity in transgenic mouse tumors reveals candidate tumor suppressor genes on chromosomes 9 and 16.

A genome-wide scan for loss of heterozygosity (LOH) in tumors provides a powerful route to the identification of genes involved in tumorigenesis. This approach has not previously been applied to transgenic mice, despite the considerable advantages they afford for genetic dissection. Here, we report...

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Publicado no:Proc Natl Acad Sci U S A
Principais autores: Dietrich, W F, Radany, E H, Smith, J S, Bishop, J M, Hanahan, D, Lander, E S
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 1994
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC44830/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7937788/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.20.9451
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