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The 26S Proteasome Degrades the Soluble but Not the Fibrillar Form of the Yeast Prion Ure2p In Vitro

Yeast prions are self-perpetuating protein aggregates that cause heritable and transmissible phenotypic traits. Among these, [PSI (+)] and [URE3] stand out as the most studied yeast prions, and result from the self-assembly of the translation terminator Sup35p and the nitrogen catabolism regulator U...

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Pubblicato in:PLoS One
Autori principali: Wang, Kai, Redeker, Virginie, Madiona, Karine, Melki, Ronald, Kabani, Mehdi
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2015
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4482727/
https://ncbi.nlm.nih.gov/pubmed/26115123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0131789
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