Mechanisms of Fatal Cardiotoxicity following High-Dose Cyclophosphamide Therapy and a Method for Its Prevention

Observed only after administration of high doses, cardiotoxicity is the dose-limiting effect of cyclophosphamide (CY). We investigated the poorly understood cardiotoxic mechanisms of high-dose CY. A rat cardiac myocardial cell line, H9c2, was exposed to CY metabolized by S9 fraction of rat liver hom...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Nishikawa, Takuro, Miyahara, Emiko, Kurauchi, Koichiro, Watanabe, Erika, Ikawa, Kazuro, Asaba, Kousuke, Tanabe, Takayuki, Okamoto, Yasuhiro, Kawano, Yoshifumi
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4482695/
https://ncbi.nlm.nih.gov/pubmed/26114497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0131394
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