Motor and Sensory Deficits in the teetering Mice Result from Mutation of the ESCRT Component HGS

Neurons are particularly vulnerable to perturbations in endo-lysosomal transport, as several neurological disorders are caused by a primary deficit in this pathway. In this report, we used positional cloning to show that the spontaneously occurring neurological mutation teetering (tn) is a single nu...

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Detalhes bibliográficos
Publicado no:PLoS Genet
Main Authors: Watson, Jennifer A., Bhattacharyya, Bula J., Vaden, Jada H., Wilson, Julie A., Icyuz, Mert, Howard, Alan D., Phillips, Edward, DeSilva, Tara M., Siegal, Gene P., Bean, Andrew J., King, Gwendalyn D., Phillips, Scott E., Miller, Richard J., Wilson, Scott M.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4482608/
https://ncbi.nlm.nih.gov/pubmed/26115514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1005290
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