Motor and Sensory Deficits in the teetering Mice Result from Mutation of the ESCRT Component HGS

Neurons are particularly vulnerable to perturbations in endo-lysosomal transport, as several neurological disorders are caused by a primary deficit in this pathway. In this report, we used positional cloning to show that the spontaneously occurring neurological mutation teetering (tn) is a single nu...

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Vydáno v:PLoS Genet
Hlavní autoři: Watson, Jennifer A., Bhattacharyya, Bula J., Vaden, Jada H., Wilson, Julie A., Icyuz, Mert, Howard, Alan D., Phillips, Edward, DeSilva, Tara M., Siegal, Gene P., Bean, Andrew J., King, Gwendalyn D., Phillips, Scott E., Miller, Richard J., Wilson, Scott M.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2015
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4482608/
https://ncbi.nlm.nih.gov/pubmed/26115514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1005290
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