Motor and Sensory Deficits in the teetering Mice Result from Mutation of the ESCRT Component HGS

Neurons are particularly vulnerable to perturbations in endo-lysosomal transport, as several neurological disorders are caused by a primary deficit in this pathway. In this report, we used positional cloning to show that the spontaneously occurring neurological mutation teetering (tn) is a single nu...

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Publicat a:PLoS Genet
Autors principals: Watson, Jennifer A., Bhattacharyya, Bula J., Vaden, Jada H., Wilson, Julie A., Icyuz, Mert, Howard, Alan D., Phillips, Edward, DeSilva, Tara M., Siegal, Gene P., Bean, Andrew J., King, Gwendalyn D., Phillips, Scott E., Miller, Richard J., Wilson, Scott M.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2015
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4482608/
https://ncbi.nlm.nih.gov/pubmed/26115514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1005290
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