Indoleamine 2,3 Dioxygenase (IDO) Expression and Activity in Relapsing- Remitting Multiple Sclerosis

BACKGROUND: Interferon gamma (IFN-γ) production induces the transcription of indoleamine 2,3 dioxygenase (IDO) resulting in the reduction of T-cell activation and proliferation through the depletion of tryptophan and the elicitation of Treg lymphocytes. IDO was shown to be involved in the pathogenes...

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Bibliographic Details
Published in:PLoS One
Main Authors: Mancuso, Roberta, Hernis, Ambra, Agostini, Simone, Rovaris, Marco, Caputo, Domenico, Fuchs, Dietmar, Clerici, Mario
Format: Artigo
Language:Inglês
Published: Public Library of Science 2015
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4482492/
https://ncbi.nlm.nih.gov/pubmed/26110930
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0130715
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