ABC Transporters and the Proteasome Complex Are Implicated in Susceptibility to Stevens–Johnson Syndrome and Toxic Epidermal Necrolysis across Multiple Drugs

Stevens–Johnson syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) represent rare but serious adverse drug reactions (ADRs). Both are characterized by distinctive blistering lesions and significant mortality rates. While there is evidence for strong drug-specific genetic predisposition related to H...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Nicoletti, Paola, Bansal, Mukesh, Lefebvre, Celine, Guarnieri, Paolo, Shen, Yufeng, Pe’er, Itsik, Califano, Andrea, Floratos, Aris
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4482486/
https://ncbi.nlm.nih.gov/pubmed/26110827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0131038
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