TNFα Signaling Regulates Cystic Epithelial Cell Proliferation through Akt/mTOR and ERK/MAPK/Cdk2 Mediated Id2 Signaling

Tumor necrosis factor alpha (TNFα) is present in cyst fluid and promotes cyst growth in autosomal dominant polycystic kidney disease (ADPKD). However, the cross-talk between TNFα and PKD associated signaling pathways remains elusive. In this study, we found that stimulation of renal epithelial cells...

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Bibliographic Details
Published in:PLoS One
Main Authors: Zhou, Julie X., Fan, Lucy X., Li, Xiaoyan, Calvet, James P., Li, Xiaogang
Format: Artigo
Language:Inglês
Published: Public Library of Science 2015
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4482222/
https://ncbi.nlm.nih.gov/pubmed/26110849
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0131043
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