Inhibition of histone deacetylases targets the transcription regulator Id2 to attenuate cystic epithelial cell proliferation

The pan-histone deacetylase (HDAC) inhibitor, trichostatin A, was found to reduce cyst progression and slow the decline of kidney function in Pkd2 knockout mice, model of autosomal dominant polycystic kidney disease (ADPKD). Here we determine whether HDAC inhibition acts by regulating cell prolifera...

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Main Authors: Fan, Lucy X., Li, Xinjian, Magenheimer, Brenda, Calvet, James P., Li, Xiaogang
Formato: Artigo
Idioma:Inglês
Publicado: 2011
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3409467/
https://ncbi.nlm.nih.gov/pubmed/21900881
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ki.2011.296
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