Combinatorial Sec pathway analysis for improved heterologous protein secretion in Bacillus subtilis: identification of bottlenecks by systematic gene overexpression

BACKGROUND: Secretory expression of valuable proteins by B. subtilis and its related species has attracted intensive work over the past three decades. Although very high yields can be achieved with homologous proteins, production of heterologous proteins by B. subtilis is unfortunately not the strai...

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Gepubliceerd in:Microb Cell Fact
Hoofdauteurs: Chen, Jingqi, Fu, Gang, Gai, Yuanming, Zheng, Ping, Zhang, Dawei, Wen, Jianping
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: BioMed Central 2015
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Research
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4482152/
https://ncbi.nlm.nih.gov/pubmed/26112883
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12934-015-0282-9
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