Activation of nociceptin opioid peptide (NOP) receptor impairs contextual fear learning in mice through glutamatergic mechanisms

The present study investigated whether the selective nociceptin opioid peptide (NOP) receptor agonist, Ro64-6198, impairs acquisition of fear conditioning through glutamatergic mechanisms. Systemic administration of Ro64-6198 (0.3 and 1 mg/kg) or the non-competitive NMDA receptor antagonist, MK-801...

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Bibliographic Details
Published in:Neurobiol Learn Mem
Main Authors: Goeldner, Celia, Reiss, Davids, Wichmann, Jürgen, Kieffer, Brigitte L., Ouagazzal, Abdel-Mouttalib
Format: Artigo
Language:Inglês
Published: 2009
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4482120/
https://ncbi.nlm.nih.gov/pubmed/19100850
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nlm.2008.12.001
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