Secretion of Fc-amidated peptide fusion proteins by Chinese hamster ovary cells

BACKGROUND: The therapeutic use of α-amidated peptides (e.g. calcitonin, glucagon-like peptide) has increased dramatically, but there are major impediments to wider use of such peptides. Larger peptides are expensive to synthesize, and short plasma half-lives frequently limit the clinical circumstan...

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Pubblicato in:BMC Biotechnol
Autori principali: Carlson, Kristina R., Pomerantz, Steven C., Li, Jiali, Vafa, Omid, Naso, Michael, Strohl, William, Mains, Richard E., Eipper, Betty A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2015
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4482046/
https://ncbi.nlm.nih.gov/pubmed/26116580
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12896-015-0173-5
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