Keys to Lipid Selection in Fatty Acid Amide Hydrolase Catalysis: Structural Flexibility, Gating Residues and Multiple Binding Pockets

The fatty acid amide hydrolase (FAAH) regulates the endocannabinoid system cleaving primarily the lipid messenger anandamide. FAAH has been well characterized over the years and, importantly, it represents a promising drug target to treat several diseases, including inflammatory-related diseases and...

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Detalhes bibliográficos
Publicado no:PLoS Comput Biol
Main Authors: Palermo, Giulia, Bauer, Inga, Campomanes, Pablo, Cavalli, Andrea, Armirotti, Andrea, Girotto, Stefania, Rothlisberger, Ursula, De Vivo, Marco
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4481349/
https://ncbi.nlm.nih.gov/pubmed/26111155
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1004231
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