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A Novel Mutation in Isoform 3 of the Plasma Membrane Ca(2+) Pump Impairs Cellular Ca(2+) Homeostasis in a Patient with Cerebellar Ataxia and Laminin Subunit 1α Mutations
The particular importance of Ca(2+) signaling to neurons demands its precise regulation within their cytoplasm. Isoform 3 of the plasma membrane Ca(2+) ATPase (the PMCA3 pump), which is highly expressed in brain and cerebellum, plays an important role in the regulation of neuronal Ca(2+). A genetic...
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| Pubblicato in: | J Biol Chem |
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| Autori principali: | , , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Biochemistry and Molecular Biology
2015
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4481214/ https://ncbi.nlm.nih.gov/pubmed/25953895 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.656496 |
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