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Hepatic SirT1-Dependent Gain-of-Function of Stearoyl-CoA Desaturase-1 Conveys Dysmetabolic and Tumor Progression Functions
Obesity is associated with higher incidence of cancer but the predisposing mechanisms remain poorly understood. The NAD(+)–dependent deacetylase SirT1 orchestrates metabolism, cellular survival, and growth. To date, there is no unifying mechanism to explain the metabolic and tumor-related effects of...
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| Publicado no: | Cell Rep |
|---|---|
| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4481188/ https://ncbi.nlm.nih.gov/pubmed/26074075 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.05.025 |
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