Hepatic SirT1-Dependent Gain-of-Function of Stearoyl-CoA Desaturase-1 Conveys Dysmetabolic and Tumor Progression Functions

Obesity is associated with higher incidence of cancer but the predisposing mechanisms remain poorly understood. The NAD(+)–dependent deacetylase SirT1 orchestrates metabolism, cellular survival, and growth. To date, there is no unifying mechanism to explain the metabolic and tumor-related effects of...

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Vydáno v:Cell Rep
Hlavní autoři: Qiang, Li, Kon, Ning, Zhao, Wenhui, Jiang, Le, Knight, Colette M., Welch, Carrie, Pajvani, Utpal, Gu, Wei, Accili, Domenico
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4481188/
https://ncbi.nlm.nih.gov/pubmed/26074075
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.05.025
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