Recombinant Soluble Respiratory Syncytial Virus F Protein That Lacks Heptad Repeat B, Contains a GCN4 Trimerization Motif and Is Not Cleaved Displays Prefusion-Like Characteristics

The respiratory syncytial virus (RSV) fusion protein F is considered an attractive vaccine candidate especially in its prefusion conformation. We studied whether recombinant soluble RSV F proteins could be stabilized in a prefusion-like conformation by mutation of heptad repeat B (HRB). The results...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Widjaja, Ivy, Rigter, Alan, Jacobino, Shamir, van Kuppeveld, Frank J. M., Leenhouts, Kees, Palomo, Concepción, Melero, Jose A., Leusen, Jeanette H. W., Haijema, Bert Jan, Rottier, Peter J. M., de Haan, Cornelis A. M.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4481108/
https://ncbi.nlm.nih.gov/pubmed/26107504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0130829
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