Preclinical analysis of the anti-tumor and anti-metastatic effects of Raf265 on colon cancer cells and CD26(+) cancer stem cells in colorectal carcinoma

BACKGROUND: In colorectal carcinoma (CRC), activation of the Raf/MEK/ERK signaling pathway is commonly observed. In addition, the commonly used 5FU-based chemotherapy in patients with metastatic CRC was found to enrich a subpopulation of CD26(+) cancer stem cells (CSCs). As activation of the Raf/MEK...

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Detalhes bibliográficos
Publicado no:Mol Cancer
Main Authors: Chow, Ariel KM, Cheng, Nathan SM, Lam, Colin SC, Ng, Lui, Wong, Sunny KM, Wan, Timothy MH, Man, Johnny HW, Cheung, Alvin HK, Yau, Thomas CC, Poon, Jensen TC, Law, Wai-Lun, Pang, Roberta WC
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4481075/
https://ncbi.nlm.nih.gov/pubmed/25884645
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12943-015-0352-y
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