Overexpression of thymidylate synthase (TYMS) is associated with aggressive tumor features and early PSA recurrence in prostate cancer

Thymidylate synthase (TYMS) plays a role in DNA synthesis and is a target for 5-fluorouracil. In this study TYMS was analyzed by immunohistochemistry on a tissue microarray containing 11,152 prostate cancers. TYMS expression was higher in neoplastic than in normal prostate epithelium and was detecta...

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Vydáno v:Oncotarget
Hlavní autoři: Burdelski, Christoph, Strauss, Christian, Tsourlakis, Maria Christina, Kluth, Martina, Hube-Magg, Claudia, Melling, Nathaniel, Lebok, Patrick, Minner, Sarah, Koop, Christina, Graefen, Markus, Heinzer, Hans, Wittmer, Corinna, Krech, Till, Sauter, Guido, Wilczak, Waldemar, Simon, Ronald, Schlomm, Thorsten, Steurer, Stefan
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2015
Témata:
Clinical Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4480759/
https://ncbi.nlm.nih.gov/pubmed/25762627
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