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The genetics of folate metabolism and maternal risk of birth of a child with Down syndrome and associated congenital heart defects
Almost 15 years ago it was hypothesized that polymorphisms of genes encoding enzymes involved in folate metabolism could lead to aberrant methylation of peri-centromeric regions of chromosome 21, favoring its abnormal segregation during maternal meiosis. Subsequently, more than 50 small case-control...
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| Publicado no: | Front Genet |
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| Autor principal: | |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Frontiers Media S.A.
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4479818/ https://ncbi.nlm.nih.gov/pubmed/26161087 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fgene.2015.00223 |
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