Preclinical Potency and Biodistribution Studies of an AAV 5 Vector Expressing Human Interferon-β (ART-I02) for Local Treatment of Patients with Rheumatoid Arthritis

INTRODUCTION: Proof of concept for local gene therapy for the treatment of arthritis with immunomodulatory cytokine interferon beta (IFN-β) has shown promising results in animal models of rheumatoid arthritis (RA). For the treatment of RA patients, we engineered a recombinant adeno-associated seroty...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Aalbers, Caroline J., Bevaart, Lisette, Loiler, Scott, de Cortie, Karin, Wright, J. Fraser, Mingozzi, Federico, Tak, Paul P., Vervoordeldonk, Margriet J.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4479517/
https://ncbi.nlm.nih.gov/pubmed/26107769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0130612
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