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Prevalence and pharmacological modulation of humoral immunity to AAV vectors in gene transfer to synovial tissue
Antibodies against adeno-associated viral (AAV) vectors are highly prevalent in humans. Both preclinical and clinical studies showed that antibodies against AAV block transduction even at low titers, particularly when the vector is introduced into the bloodstream. Here we measured the neutralizing a...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3473155/ https://ncbi.nlm.nih.gov/pubmed/22786533 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/gt.2012.55 |
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