Prevalence and pharmacological modulation of humoral immunity to AAV vectors in gene transfer to synovial tissue

Antibodies against adeno-associated viral (AAV) vectors are highly prevalent in humans. Both preclinical and clinical studies showed that antibodies against AAV block transduction even at low titers, particularly when the vector is introduced into the bloodstream. Here we measured the neutralizing a...

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Bibliografske podrobnosti
Main Authors: Mingozzi, F, Chen, Y, Edmonson, S C, Zhou, S, Thurlings, R M, Tak, P P, High, K A, Vervoordeldonk, M J
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2013
Teme:
Original Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3473155/
https://ncbi.nlm.nih.gov/pubmed/22786533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/gt.2012.55
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