Axl Inhibition Primes Chronic Lymphocytic Leukemia B-Cells to Apoptosis and Show Synergistic/Additive Effects in Combination with BTK inhibitors

PURPOSE: B-cell chronic lymphocytic leukemia (CLL) is an incurable disease despite aggressive therapeutic approaches. We previously found that Axl receptor tyrosine kinase (RTK) plays a critical role in CLL B-cell survival. Here, we explored the possibility of using a high-affinity Axl inhibitor as...

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Bibliografiske detaljer
Udgivet i:Clin Cancer Res
Main Authors: Sinha, Sutapa, Boysen, Justin, Nelson, Michael, Secreto, Charla, Warner, Steven L., Bearss, David J., Lesnick, Connie, Shanafelt, Tait D., Kay, Neil E., Ghosh, Asish K.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4479154/
https://ncbi.nlm.nih.gov/pubmed/25673699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-14-1892
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