Reinforcement of STAT3 activity reprogrammes human embryonic stem cells to naive-like pluripotency

Leukemia inhibitory factor (LIF)/STAT3 signalling is a hallmark of naive pluripotency in rodent pluripotent stem cells (PSCs), whereas fibroblast growth factor (FGF)-2 and activin/nodal signalling is required to sustain self-renewal of human PSCs in a condition referred to as the primed state. It is...

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Udgivet i:Nat Commun
Main Authors: Chen, Hongwei, Aksoy, Irène, Gonnot, Fabrice, Osteil, Pierre, Aubry, Maxime, Hamela, Claire, Rognard, Cloé, Hochard, Arnaud, Voisin, Sophie, Fontaine, Emeline, Mure, Magali, Afanassieff, Marielle, Cleroux, Elouan, Guibert, Sylvain, Chen, Jiaxuan, Vallot, Céline, Acloque, Hervé, Genthon, Clémence, Donnadieu, Cécile, De Vos, John, Sanlaville, Damien, Guérin, Jean- François, Weber, Michael, Stanton, Lawrence W, Rougeulle, Claire, Pain, Bertrand, Bourillot, Pierre-Yves, Savatier, Pierre
Format: Artigo
Sprog:Inglês
Udgivet: Nature Pub. Group 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4479042/
https://ncbi.nlm.nih.gov/pubmed/25968054
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms8095
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