FUS regulates AMPA receptor function and FTLD/ALS-associated behaviour via GluA1 mRNA stabilization

FUS is an RNA/DNA-binding protein involved in multiple steps of gene expression and is associated with amyotrophic lateral sclerosis (ALS) and fronto-temporal lobar degeneration (FTLD). However, the specific disease-causing and/or modifying mechanism mediated by FUS is largely unknown. Here we evalu...

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Gepubliceerd in:Nat Commun
Hoofdauteurs: Udagawa, Tsuyoshi, Fujioka, Yusuke, Tanaka, Motoki, Honda, Daiyu, Yokoi, Satoshi, Riku, Yuichi, Ibi, Daisuke, Nagai, Taku, Yamada, Kiyofumi, Watanabe, Hirohisa, Katsuno, Masahisa, Inada, Toshifumi, Ohno, Kinji, Sokabe, Masahiro, Okado, Haruo, Ishigaki, Shinsuke, Sobue, Gen
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Pub. Group 2015
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4479014/
https://ncbi.nlm.nih.gov/pubmed/25968143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms8098
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