A GMCSF and IL7 fusion cytokine leads to functional thymic-dependent T-cell regeneration in age-associated immune deficiency

The competence of cellular immunity depends on a diverse T-cell receptor (TCR) repertoire arising from thymic output. Normal thymopoiesis arises from marrow-derived CD3(−)CD4(−)CD8(−) triple-negative T-cell progenitors (TN), which develop into mature single-positive (SP) CD4 or CD8 T cells after exp...

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Detalhes bibliográficos
Publicado no:Clin Transl Immunology
Main Authors: Hsieh, Jeremy, Ng, Spencer, Bosinger, Steve, Wu, Jian Hui, Tharp, Gregory K, Garcia, Anapatricia, Hossain, Mohammad S, Yuan, Shala, Waller, Edmund K, Galipeau, Jacques
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4478872/
https://ncbi.nlm.nih.gov/pubmed/26131365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cti.2015.8
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