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Stimulation of natural killer cell-mediated tumor immunity by an IL-15/TGF-ß neutralizing fusion protein
The clinical efficacy of immune cytokines used for cancer therapy is hampered by elements of the immunosuppressive tumor microenvironment such as TGF-ß. Here we demonstrate that FIST15, a recombinant chimeric protein composed of the T cell stimulatory cytokine IL-15, the sushi domain of IL15Rα and a...
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| Pubblicato in: | Cancer Res |
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| Autori principali: | , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2016
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5050108/ https://ncbi.nlm.nih.gov/pubmed/27488533 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-16-0386 |
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