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Stimulation of natural killer cell-mediated tumor immunity by an IL-15/TGF-ß neutralizing fusion protein

The clinical efficacy of immune cytokines used for cancer therapy is hampered by elements of the immunosuppressive tumor microenvironment such as TGF-ß. Here we demonstrate that FIST15, a recombinant chimeric protein composed of the T cell stimulatory cytokine IL-15, the sushi domain of IL15Rα and a...

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Bibliographic Details
Published in:Cancer Res
Main Authors: Ng, Spencer, Deng, Jiusheng, Chinnadurai, Raghavan, Yuan, Shala, Pennati, Andrea, Galipeau, Jacques
Format: Artigo
Language:Inglês
Published: 2016
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5050108/
https://ncbi.nlm.nih.gov/pubmed/27488533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-16-0386
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